E-Journal Club februar 2020

Vi møder alle sammen forældre, der af forskellige grunde har valgt at takke nej til børnevaccinationsprogrammet. Èt af de argumenter vi kan møde, er at det er unaturligt at blive vaccineret, og det er bedre for børnene at møde de rigtige sygdomme. I dette studie har man undersøgt en gruppe hollandske børn før og efter en mæslingeepidemi med en ny metode kaldet VirScan. Undersøgelsen sætter en pæl gennem ovenstående påstand, da den viser, at børnene mister en stor del af deres humorale hukommelse i forbindelse med en mæslingeinfektion, men ikke ved vaccination med mæslingeholdig-vaccine.

 

Measles virus infection diminishes preexisting antibodies that offer protection from other pathogens

 

Mina MJ et al
Science

 

https://www.ncbi.nlm.nih.gov/pubmed/31672891

 

Abstract
Measles virus is directly responsible for more than 100,000 deaths yearly. Epidemiological studies have associated measles with increased morbidity and mortality for years after infection, but the reasons why are poorly understood. Measles virus infects immune cells, causing acute immune suppression. To identify and quantify long-term effects of measles on the immune system, we used VirScan, an assay that tracks antibodies to thousands of pathogen epitopes in blood. We studied 77 unvaccinated children before and 2 months after natural measles virus infection. Measles caused elimination of 11 to 73% of the antibody repertoire across individuals. Recovery of antibodies was detected after natural reexposure to pathogens. Notably, these immune system effects were not observed in infants vaccinated against MMR (measles, mumps, and rubella), but were confirmed in measles-infected macaques. The reduction in humoral immune memory after measles infection generates potential vulnerability to future infections, underscoring the need for widespread vaccination.

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